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Richard Castillo, Ph.D.

My research is focused largely on the use of deformable image registration (DIR) in medical image analysis and functional lung imaging from computed tomography (CT). Deformable registration is a quickly developing technology with many potential applications in diagnostic imaging and radiotherapy. However, methods for evaluation and formal validation of novel DIR models and implementations are lacking. My research in this area involves investigation of quantitative/statistical methods for evaluation of DIR spati accuracy for purposes of validation and acceptance testing, as well as quality assurance in routine clinical application.

I am also actively investigating methods for utilizing DIR output to extract functional information, including quantitative pulmonary ventilation and perfusion, from treatment planning 4D CT, as well as from breath-hold CT image pairs acquired in the diagnostic setting. The incorporation of such function information into radiotherapy treatment planning for purposes of functional avoidance may prove to be a superior planning practice for the treatment of thoracic malignancies.

Contact Information

Mailing Address:

Richard Castillo, Ph.D.
Post-doctoral Fellow
Department of Radiation Oncology - Unit 97
The University of Texas M. D. Anderson Cancer Center
1515 Holcombe Blvd
Houston, TX 77030

Phone: +1-713-563-2597
Email: RiCastillo@MDAnderson.org

Curriculum Vitae

RichardCastilloCV.pdf

Publications

Peer Reviewed Publications:

1. Yevgeniy Y. Vinogradskiy, Richard Castillo, Edward Castillo, Adam Chandler, Mary K. Martel, and Thomas Guerrero. Use of Weekly 4DCT-based Ventilation Maps to Quantify Changes in Lung Function for Patients Undergoing Radiation Therapy. ARTICLE IN PRESS: Medical Physics.
2. Richard Castillo, Edward Castillo, Josue Martinez, Thomas Guerrero. Ventilation from Four Dimensional Computed Tomography: Density versus Jacobian Methods. Physics in Medicine & Biology, 55: 4661-4685, 2010.
3. Xuejun Gu, Hubert Pan, Yun Liang, Richard Castillo, Deshan Yang, Dongju Choi, Edward Castillo, Amitava Majumdar, Thomas Guerrero, Steven B. Jiang. Implementation and evaluation of various demons deformable image registration algorithms on GPU. Physics in Medicine & Biology, 55: 207-219, 2010.
4. Edward Castillo, Richard Castillo, Josue Martinez, Maithili Shenoy, Thomas Guerrero. Four dimensional deformable image registration using trajectory modeling. Physics in Medicine & Biology, 55: 305-327, 2010.
5. Edward Castillo, Richard Castillo, Yin Zhang, Thomas Guerrero. Compressible image registration for thoracic computed tomography images. Journal of Medical and Biomedical Engineering, 29: 222-233, 2009.
6. Richard Castillo, Edward Castillo, Rudy Guerra, Valen Johnson, Travis McPhail, Amit K. Garg, Thomas Guerrero. A framework for evaluation of deformable image registration spatial accuracy using large landmark point sets. Physics in Medicine & Biology; 54: 1849-1870, 2009.**
7. Thomas Guerrero, Richard Castillo, Josue Noyola-Martinez, Mylin Torres, Xinhui Zhou, Rudy Guerra, Dianna Cody, Ritsuko Komaki, Elizabeth Travis. Reduction of pulmonary compliance found with high-resolution computed tomography in irradiated mice. International Journal of Radiation Oncology*Biology*Physics, 67: 879-887, 2007.
8. Thomas Guerrero, Richard Castillo, Kevin Sanders, Roger Price, Ritsuko Komaki, Dianna Cody. Novel method to calculate pulmonary compliance images in rodents from computed tomography acquired at constant pressures. Physics in Medicine & Biology, 51: 1101-1112, 2006.
9. Tinsu Pan, Osama Mawlawi, Sadek A. Nehmeh, Yusuf E. Erdi, Dershan Luo, Hui H. Liu, Richard Castillo, Radhe Mohan, Zhongxing Liao, H. A. Macapinlac. Attenuation correction of PET images with respiration-averaged CT images in PET/CT. The Journal of Nuclear Medicine, 46: 1481-1487, 2005.

** Top 10 cited article in the past two years in the journal "Physics in Medicine & Biology" (Commendation in 2011) **

Manuscripts Presently in Review:

1. Alfredo E. Echeverria, Matthew R. McCurdy, Richard Castillo, Vincent Bernard, Natalia V. Ramos, William R. Buckley, Edward Castillo, Ping Liu, Eric D. Hyun, and Thomas Guerrero. Proton Therapy Radiation Pneumonitis Local Dose-Response in Esophagus Cancer Patients. SUBMITTED: Radiotherapy and Oncology.
2. Edward Castillo, Richard Castillo, and Thomas Guerrero. Least median of squares filtering of locally optimal point matches for compressible flow image registration. SUBMITTED: Journal of Medical and Biomedical Engineering.
3. Richard Castillo, Edward Castillo, Matthew R. McCurdy, Daniel R. Gomez, Alec M. Block, Derek Bergsma, Sarah Joy, and Thomas Guerrero. Spatial Correspondence of 4D CT Ventilation and SPECT Pulmonary Perfusion Defects in Patients with Malignant Airway Stenosis. SUBMITTED: Physics in Medicine & Biology.
4. Lindsay Mathew, Richard Castillo, Edward Castillo, Brian Yaremko, George B. Rodrigues, Grace Parraga, and Thomas Guerrero. Comparison of 3He Magnetic Resonance Imaging and Four-dimensional x-ray Computed Tomography Pulmonary Functional Imaging in Lung Cancer. SUBMITTED: Radiology.
5. Matthew McCurdy, Richard Castillo, Josue Martinez, Mohammad N Al Hallack, Jessica Lichter, Nicolas Zouain, and Thomas Guerrero. [18F]-FDG Uptake Dose Correlates with Radiation Pneumonitis in Lung Cancer Patients. SUBMITTED: Radiotherapy and Oncology.

Presentations

Conference Talks:

• American Association of Physicists in Medicine (AAPM) Annual Meeting, Philadelphia, PA. Ventilation from Four Dimensional Computed Tomography: Density versus Jacobian Methods. July 2010.

My Dissertation Defense Presentation:

• Evaluation of Deformable Image Registration for Improved 4D CT-Derived Ventilation for Image Guided Radiotherapy. September 2011.

Invited Lectures:

• London Regional Cancer Center, Thoracic Rounds Meeting, Numerical Methods for Computing Ventilation from Thoracic CT, September 2010.
• University of California San Diego, Pulmonology Group Seminar, Quantifying Regional Ventilation using Computed Tomography: Applications in Diagnostic Imaging and Thoracic Radiotherapy, June 2010.
• University of California San Diego, Department of Radiation Physics, Evaluation of Deformable Image Registration for Improved 4D CT-Derived Ventilation Image Generation, June 2009.
• University of Texas M. D. Anderson Cancer Center, Department of Radiation Physics, Performance Evaluation of Deformable Image Registration, January 2009.

Other:

• Richard Castillo, Edward Castillo, Daniel Gomez, Jose Lopez, and Thomas Guerrero. American Association of Physicists in Medicine (AAPM) Annual Meeting, Vancouver, British Columbia, John R. Cunningham Young Investigator Competition Finalist, Spatial Correlation of 4DCT Ventilation and SPECT Pulmonary Perfusion Defects in Patients with Malignant Airway Stenosis. July 2011.
• Yevgeny Vinogradskiy, Richard Castillo, Edward Castillo, Adam Chandler, Mary Martel, and Thomas Guerrero. American Association of Physicists in Medicine (AAPM) Annual Meeting, Vancouver, British Columbia, Use of Weekly 4DCT-Based Ventilation Maps to Quantify Changes in Lung Function for Patients Undergoing Radiation Therapy. July 2011.
• Matthew McCurdy, Mohamad Wazni, Josue Martinez, Richard Castillo, and Thomas Guerrero. American Association of Physicists in Medicine (AAPM) Annual Meeting, Vancouver, British Columbia, Post-Radiation Normalized FDG-PET Versus Radiation Dose Correlates with Radiation Pneumonitis Symptoms and the Nitric Oxide Ratio. July 2011.
• Richard Castillo, Edward Castillo, Josue Martinez, and Thomas Guerrero. American Association of Physicists in Medicince (AAPM) Annual Meeting, Philadelphia, PA, Ventilation from Four-Dimensional Computed Tomography: Density versus Jacobian Methods. July 2010.
• Matthew McCurdy, Maithili Shenoy, Josue Martinez, Richard Castillo, and Thomas Guerrero. American Radium Society (ARS) Annual Meeting, Cancun, Mexico, Radiation Response of the Upper versus Lower Lung Lobes. May 2010.
• Thomas Guerrero, Matthew McCurdy, Ivorlyne Greene, Jan Pagilagan, and Richard Castillo. National Cancer Institute (NCI) Translational Science Annual Meeting, Vienna, Virginia, Validation of the Pulmonary Metabolic Radiation Response as An Imaging Biomarker. Novermber 2009.
• Matthew McCurdy, Josue Martinez, Richard Castillo, Nicolas Zouain, and Thomas Guerrero. American Society for Therapeutic Radiology and Oncology (ASTRO) Annual Meeting, Chicago, IL, Radiation Pneumonitis: Pulmonary Metabolic Response to Radiation in Lung Cancer Patients. November 2009.
• Richard Castillo, Travis McPhail, Rudy Guerra, Edward Castillo, Joe Warren, Amit K. Garg, and Thomas Guerrero. ASTRO Annual Meeting, Boston, MA, Interior Landmark Point Pairs Improve Deformable Image Registration Spatial Accuracy Within the Lung. September 2008.